Title : A role for phospholipase C activity in GLUT4-mediated glucose transport.

Pub. Date : 1997 Dec

PMID : 9389497






3 Functional Relationships(s)
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1 Overexpression of surrogate receptors [epidermal growth factor (EGF) receptor (EGFR) and platelet-derived growth factor receptor] in adipocytes has demonstrated that multiple signaling pathways may lead to GLUT4-mediated glucose uptake. Glucose epidermal growth factor receptor Homo sapiens
2 In addition, we previously demonstrated that EGFR tyrosyl autophosphorylation is required to stimulate GLUT4-mediated glucose transport in 3T3-L1 adipocytes. Glucose epidermal growth factor receptor Homo sapiens
3 This observation suggests that signaling molecules that are dependent on EGFR autophosphorylation, such as phospholipase C (PLC), may lie in the signaling pathway to glucose transport. Glucose epidermal growth factor receptor Homo sapiens