Title : Hexokinase binding to mitochondria: a basis for proliferative energy metabolism.

Pub. Date : 1997 Aug

PMID : 9387093






2 Functional Relationships(s)
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1 Drawing on the hexokinase-mitochondrial acceptor theory of insulin action, this article presents evidence suggesting that the increased binding of hexokinase to porin on mitochondria of cancer cells not only accelerates glycolysis by providing hexokinase with better access to ATP, but also stimulates the TCA cycle by providing the mitochondrion with ADP that acts as an acceptor for phosphoryl groups. Adenosine Diphosphate hexokinase 1 Homo sapiens
2 Drawing on the hexokinase-mitochondrial acceptor theory of insulin action, this article presents evidence suggesting that the increased binding of hexokinase to porin on mitochondria of cancer cells not only accelerates glycolysis by providing hexokinase with better access to ATP, but also stimulates the TCA cycle by providing the mitochondrion with ADP that acts as an acceptor for phosphoryl groups. Adenosine Diphosphate hexokinase 1 Homo sapiens