Title : Enhancement of spontaneous baroreflex by antisense c-fos oligonucleotide treatment in the NTS of the rat.

Pub. Date : 1997 Nov

PMID : 9374754






2 Functional Relationships(s)
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1 Enhancement of spontaneous baroreflex by antisense c-fos oligonucleotide treatment in the NTS of the rat. Oligonucleotides Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 In adult male Sprague-Dawley rats anesthetized and maintained with pentobarbital sodium, microinjection bilaterally into the caudal NTS of a 15-mer antisense oligonucleotide that targets against the initiation codon of c-fos mRNA (5"-129 to 143-3") significantly enhanced the spontaneous BRR response, as determined by transfer function analysis of SAP and heart rate signals. Oligonucleotides Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus