Pub. Date : 1997 Nov 28
PMID : 9374492
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation. | sanguinarine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Sanguinarine (pseudochelerythrine) is a potent inhibitor of NF-kappaB activation, IkappaBalpha phosphorylation, and degradation. | sanguinarine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | In the present report we show that sanguinarine (a benzophenanthridine alkaloid), a known anti-inflammatory agent, is a potent inhibitor of NF-kappaB activation. | sanguinarine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Treatment of human myeloid ML-1a cells with tumor necrosis factor rapidly activated NF-kappaB, this activation was completely suppressed by sanguinarine in a dose- and time-dependent manner. | sanguinarine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | Sanguinarine did not inhibit the binding of NF-kappaB protein to the DNA but rather inhibited the pathway leading to NF-kappaB activation. | sanguinarine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 6 | The reversal of inhibitory effects of sanguinarine by reducing agents suggests a critical sulfhydryl group is involved in NF-kappaB activation. | sanguinarine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 7 | Sanguinarine blocked the tumor necrosis factor-induced phosphorylation and degradation of IkappaBalpha, an inhibitory subunit of NF-kappaB, and inhibited translocation of p65 subunit to the nucleus. | sanguinarine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 8 | As sanguinarine also inhibited NF-kappaB activation induced by interleukin-1, phorbol ester, and okadaic acid but not that activated by hydrogen peroxide or ceramide, the pathway leading to NF-kappaB activation is likely different for different inducers. | sanguinarine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 9 | As sanguinarine also inhibited NF-kappaB activation induced by interleukin-1, phorbol ester, and okadaic acid but not that activated by hydrogen peroxide or ceramide, the pathway leading to NF-kappaB activation is likely different for different inducers. | sanguinarine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 10 | Overall, our results demonstrate that sanguinarine is a potent suppressor of NF-kappaB activation and it acts at a step prior to IkappaBalpha phosphorylation. | sanguinarine | nuclear factor kappa B subunit 1 | Homo sapiens |