Pub. Date : 1997 Aug 29
PMID : 9365020
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prostaglandin E2 may induce hyperthermia through EP1 receptor in the anterior wall of the third ventricle and neighboring preoptic regions. | Dinoprostone | prostaglandin E receptor 1 | Rattus norvegicus |
| 2 | We have previously reported that intracerebroventricular injection of prostaglandin E2 (PGE2) induces hyperthermia possibly through EP1 receptors in the rat. | Dinoprostone | prostaglandin E receptor 1 | Rattus norvegicus |
| 3 | We have previously reported that intracerebroventricular injection of prostaglandin E2 (PGE2) induces hyperthermia possibly through EP1 receptors in the rat. | Dinoprostone | prostaglandin E receptor 1 | Rattus norvegicus |
| 4 | In the present study, to determine the sites in the brain where PGE2 induces hyperthermia through EP1 receptors, we microinjected an EP1 receptor agonist, 17-phenyl-omega-trinor PGE2 (17-Ph-PGE2, 100 ng) into different sites in the rat brain and observed the colonic temperature (Tco) for 2 h in a 23 +/- 1 degrees C environment. | Dinoprostone | prostaglandin E receptor 1 | Rattus norvegicus |
| 5 | In the present study, to determine the sites in the brain where PGE2 induces hyperthermia through EP1 receptors, we microinjected an EP1 receptor agonist, 17-phenyl-omega-trinor PGE2 (17-Ph-PGE2, 100 ng) into different sites in the rat brain and observed the colonic temperature (Tco) for 2 h in a 23 +/- 1 degrees C environment. | Dinoprostone | prostaglandin E receptor 1 | Rattus norvegicus |
| 6 | Intracerebroventricular pretreatment with SC-19220 (an EP1 antagonist, 100 microg) inhibited the rise in the Tco which was induced by microinjection of PGE2 (50 ng) into the A3V. | Dinoprostone | prostaglandin E receptor 1 | Rattus norvegicus |
| 7 | These results thus suggest that PGE2 induces hyperthermia by stimulating EP1 receptors in the A3V and the neighboring preoptic region. | Dinoprostone | prostaglandin E receptor 1 | Rattus norvegicus |