Title : Adrenalectomy overcomes the blunted natriuretic response to atrial natriuretic peptide during hypocapnia in rats.

Pub. Date : 1997 Nov

PMID : 9363368






3 Functional Relationships(s)
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1 In sham rats, ANP infusion at a rate of 12 micrograms/kg per h resulted in a smaller increase in the fractional excretion of sodium during hypocapnia (mean +/- SEM: 1.02 +/- 0.40%, n = 10) than normocapnia (3.95 +/- 0.64%, n = 9; P < 0.001). Sodium natriuretic peptide A Rattus norvegicus
2 The level of fractional excretion of sodium with ANP infusion during hypocapnia was not significantly different from the level in saline-infused hypocapnic sham rats (0.93 +/- 0.62%, n = 10). Sodium natriuretic peptide A Rattus norvegicus
3 In hypocapnic ADX rats (n = 11), ANP induced greater increases in the fractional excretion of sodium (5.59 +/- 1.35%) than did saline infusion (1.04 +/- 1.02%, n = 10; P < 0.002). Sodium natriuretic peptide A Rattus norvegicus