Title : Tumor necrosis factor is a brain damaging cytokine in cerebral ischemia.

Pub. Date : 1997 Nov

PMID : 9361344






1 Functional Relationships(s)
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1 Similar results were achieved by systemic administration of CNI-1493, a recently described tetravalent guanylhydrazone compound, which effectively inhibited endogenous brain TNF synthesis and conferred significant protection against the development of cerebral infarction (80% reduced infarct volume as compared with vehicle controls treated 1 h postischemia with 10 mg/kg). Mitoguazone tumor necrosis factor-like Rattus norvegicus