Title : Regulation of cGMP by soluble and particulate guanylyl cyclases in cultured human airway smooth muscle.

Pub. Date : 1997 Oct

PMID : 9357856






6 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Both SNP (10(-6) to 10(-3) M) and SNAP (10(-6) to 10(-3) M) caused concentration-dependent elevation of cGMP in the presence of the nonselective phosphodiesterase (PDE) inhibitor 3-isobutyl-1-methylxanthine (10(-3) M), with cGMP increasing 6- and 15-fold in response to SNP and SNAP, respectively, at the highest concentration tested (10(-3) M). Cyclic GMP aldehyde dehydrogenase 7 family member A1 Homo sapiens
2 Both SNP (10(-6) to 10(-3) M) and SNAP (10(-6) to 10(-3) M) caused concentration-dependent elevation of cGMP in the presence of the nonselective phosphodiesterase (PDE) inhibitor 3-isobutyl-1-methylxanthine (10(-3) M), with cGMP increasing 6- and 15-fold in response to SNP and SNAP, respectively, at the highest concentration tested (10(-3) M). Cyclic GMP aldehyde dehydrogenase 7 family member A1 Homo sapiens
3 SNAP- and ANP-induced cGMP accumulation was increased by the selective type V PDE inhibitors SKF-96231 and zaprinast, suggesting that type V PDE is responsible for cGMP breakdown in HASMC. Cyclic GMP aldehyde dehydrogenase 7 family member A1 Homo sapiens
4 SNAP- and ANP-induced cGMP accumulation was increased by the selective type V PDE inhibitors SKF-96231 and zaprinast, suggesting that type V PDE is responsible for cGMP breakdown in HASMC. Cyclic GMP aldehyde dehydrogenase 7 family member A1 Homo sapiens
5 SNAP- and ANP-induced cGMP accumulation was increased by the selective type V PDE inhibitors SKF-96231 and zaprinast, suggesting that type V PDE is responsible for cGMP breakdown in HASMC. Cyclic GMP aldehyde dehydrogenase 7 family member A1 Homo sapiens
6 SNAP- and ANP-induced cGMP accumulation was increased by the selective type V PDE inhibitors SKF-96231 and zaprinast, suggesting that type V PDE is responsible for cGMP breakdown in HASMC. Cyclic GMP aldehyde dehydrogenase 7 family member A1 Homo sapiens