Pub. Date : 1997 Oct
PMID : 9357850
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of the ICE family of proteases in silica-induced apoptosis in human alveolar macrophages. | Silicon Dioxide | caspase 1 | Homo sapiens |
| 2 | Additionally, an increased formation of the active p20 fragments of ICE and Ich-1L as well as degradation of the inactive zymogen form of cpp32beta protein were observed in silica-treated human alveolar macrophages, indicating activation of these proteases. | Silicon Dioxide | caspase 1 | Homo sapiens |
| 3 | These results suggest that silica-induced apoptosis involves activation of the ICE family of proteases and is the first step in elucidating the intracellular mechanism of particulate-induced apoptosis in human alveolar macrophages. | Silicon Dioxide | caspase 1 | Homo sapiens |