Pub. Date : 1997 Nov
PMID : 9356388
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effects of BDNF on NMDA-activated currents were examined in greater detail. | N-Methylaspartate | brain-derived neurotrophic factor | Rattus norvegicus |
| 2 | The enhancement of NMDA-activated currents by BDNF was observed using both perforated and whole cell patch recording techniques and could be demonstrated in outside-out patches. | N-Methylaspartate | brain-derived neurotrophic factor | Rattus norvegicus |
| 3 | Modulation of NMDA responses by BDNF was dependent on the concentration of extracellular glycine. | N-Methylaspartate | brain-derived neurotrophic factor | Rattus norvegicus |
| 4 | However, the competitive glycine-site antagonist 7-chloro-kynurenic acid blocked the enhancement by BDNF without shifting the dose-inhibition relationship for this antagonist, and Mg2+ consistently depressed the potentiation of NMDA-evoked currents by BDNF, indicating that BDNF does not alter glycine affinity. | N-Methylaspartate | brain-derived neurotrophic factor | Rattus norvegicus |
| 5 | However, the competitive glycine-site antagonist 7-chloro-kynurenic acid blocked the enhancement by BDNF without shifting the dose-inhibition relationship for this antagonist, and Mg2+ consistently depressed the potentiation of NMDA-evoked currents by BDNF, indicating that BDNF does not alter glycine affinity. | N-Methylaspartate | brain-derived neurotrophic factor | Rattus norvegicus |