Title : Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: effects of contents of these two forms in individual human samples.

Pub. Date : 1997 Nov

PMID : 9353355






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Omeprazole 5-hydroxylation by liver microsomes of a human sample that contained relatively high levels of CYP3A4 and low levels of CYP2C19 were inhibited very significantly by ketoconazole and anti-CYP3A4 antibodies, although a human sample having high in CYP2C19 and low in CYP3A4 was found to be sensitive toward fluvoxamine and anti-CYP2C9 antibodies. Ketoconazole cytochrome P450 family 2 subfamily C member 9 Homo sapiens