Pub. Date : 1997 Oct 31
PMID : 9346894
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain. | Tacrolimus | FKBP prolyl isomerase 1A | Homo sapiens |
| 2 | It is the primary receptor for the immunosuppressant actions of the drug FK506 in whose presence FKBP12 binds to and inhibits calcineurin, disrupting interleukin formation in lymphocytes. | Tacrolimus | FKBP prolyl isomerase 1A | Homo sapiens |
| 3 | We now report that FKBP12 binds the IP3R at residues 1400-1401, a leucyl-prolyl dipeptide epitope that structurally resembles FK506. | Tacrolimus | FKBP prolyl isomerase 1A | Homo sapiens |
| 4 | We propose that FK506 promotes an FKBP12-calcineurin interaction by mimicking structurally similar dipeptide epitopes present within proteins that use FKBP12 to anchor calcineurin to the appropriate physiologic substrates. | Tacrolimus | FKBP prolyl isomerase 1A | Homo sapiens |
| 5 | We propose that FK506 promotes an FKBP12-calcineurin interaction by mimicking structurally similar dipeptide epitopes present within proteins that use FKBP12 to anchor calcineurin to the appropriate physiologic substrates. | Tacrolimus | FKBP prolyl isomerase 1A | Homo sapiens |