Title : Synthesis of a novel sialic acid derivative (sialylphospholipid) as an antirotaviral agent.

Pub. Date : 1997 Oct 10

PMID : 9341907






2 Functional Relationships(s)
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1 PC and 1,8-octanediol were conjugated by transesterification reaction of Streptomyces phospholipase D (PLD) under a water-chloroform biphasic system to afford phosphatidyloctanol, which was condensed with a protected 2-chloro-2-deoxyneuraminic acid derivative by using silver trifluoromethanesulfonate as an activator in chloroform and converted, after deprotection, to SPL. Water glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
2 PC and 1,8-octanediol were conjugated by transesterification reaction of Streptomyces phospholipase D (PLD) under a water-chloroform biphasic system to afford phosphatidyloctanol, which was condensed with a protected 2-chloro-2-deoxyneuraminic acid derivative by using silver trifluoromethanesulfonate as an activator in chloroform and converted, after deprotection, to SPL. Water glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens