Title : Treatment of cirrhotic rats with L-ornithine-L-aspartate enhances urea synthesis and lowers serum ammonia levels.

Pub. Date : 1997 Oct

PMID : 9336301






2 Functional Relationships(s)
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1 The negative correlation between glutamine synthetase activity and plasma ammonia levels reported previously for cirrhotic rats (Gebhardt and Reichen, Hepatology 20:684-691, 1994) was corroborated for cirrhotic animals not treated with OA, but was no longer apparent in OA-treated cirrhotic rats. Ammonia glutamate-ammonia ligase Rattus norvegicus
2 Despite this improvement, plasma ammonia levels still varied considerably reflecting the variable accessibility and activities of glutamine synthetase in cirrhotics. Ammonia glutamate-ammonia ligase Rattus norvegicus