Title : Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612.

Pub. Date : 1997 Oct 21

PMID : 9335553






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 These results indicate that activation of protein kinase C stimulates a kinase which can phosphorylate insulin receptor substrate-1 at serine 612, resulting in an inhibition of insulin signaling in the cell, posing a potential mechanism for insulin resistance in some models of obesity. Serine insulin receptor Homo sapiens