Title : The critical active-site amine of the human 8-oxoguanine DNA glycosylase, hOgg1: direct identification, ablation and chemical reconstitution.

Pub. Date : 1997 Sep

PMID : 9331411






1 Functional Relationships(s)
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1 In addition, we observed that the repair-inactive but recognition-competent Cys249 mutant (Lys249-->Cys) of hOgg1 can be functionally rescued by alkylation with 2-bromoethylamine, which functionally replaces the lysine residue by generating a gamma-thia-lysine. S-2-aminoethyl cysteine 8-oxoguanine DNA glycosylase Homo sapiens