Pub. Date : 1997 Oct
PMID : 9328319
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chlormethiazole inhibition of cytochrome P450 2E1 as assessed by chlorzoxazone hydroxylation in humans. | Chlormethiazole | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 2 | Because it had been reported that chlormethiazole inhibits the alcohol-inducible cytochrome P450 2E1 in rat liver, we investigated the in vivo and in vitro effect of this drug on cytochrome P450 2E1 in human beings. | Chlormethiazole | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 3 | In addition, the effect of chlormethiazole on cytochrome P450 2E1 was studied in vitro using human liver microsomes. | Chlormethiazole | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 4 | These data clearly show that chlormethiazole is an efficient inhibitor of chlorzoxazone metabolism and thus of cytochrome P450 2E1 activity in human beings. | Chlormethiazole | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |
| 5 | Because cytochrome P450 2E1 induction after chronic ethanol consumption has detrimental effects on the liver through free radical formation, treatment of alcohol detoxification with chlormethiazole may be beneficial. | Chlormethiazole | cytochrome P450 family 2 subfamily E member 1 | Homo sapiens |