Title : Metabolism of catecholamines by catechol-O-methyltransferase in cells expressing recombinant catecholamine transporters.

Pub. Date : 1997 Oct

PMID : 9326274






1 Functional Relationships(s)
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1 Uptake and cellular retention of 3H-catecholamines was increased by up to fourfold by two COMT inhibitors, tropolone and Ro 41-0960, with potencies similar to those for inhibition of COMT activity, whereas the uptake of two transporter substrates that are not substrates for COMT, [3H]serotonin and [3H]MPP+, was unaffected. Serotonin catechol-O-methyltransferase Homo sapiens