Title : gamma-Glutamyl hydrolase and folylpolyglutamate synthetase activities predict polyglutamylation of methotrexate in acute leukemias.

Pub. Date : 1997

PMID : 9306433






3 Functional Relationships(s)
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1 The ratio between GGH and FPGS activities was better at predicting the amount of polyglutamate accumulated in the 24-h [3H]MTX assay compared to the determination of either activity alone. Polyglutamic Acid folylpolyglutamate synthase Homo sapiens
2 The linear regression curve relating the relative levels of long-chain polyglutamates/total polyglutamates with the ratio of GGH/FPGS showed an r value of 0.81 (P < 0.001). Polyglutamic Acid folylpolyglutamate synthase Homo sapiens
3 The linear regression curve relating the relative levels of long-chain polyglutamates/total polyglutamates with the ratio of GGH/FPGS showed an r value of 0.81 (P < 0.001). Polyglutamic Acid folylpolyglutamate synthase Homo sapiens