Title : Bactericidal activity against intermediately cephalosporin-resistant Streptococcus pneumoniae in cerebrospinal fluid of children with bacterial meningitis treated with high doses of cefotaxime and vancomycin.

Pub. Date : 1997 Sep

PMID : 9303415






3 Functional Relationships(s)
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1 Cerebrospinal fluid (CSF) was taken from 19 children with bacterial meningitis treated with cefotaxime (300 mg/kg of body weight/day) and vancomycin (60 mg/kg/day). Cefotaxime colony stimulating factor 2 Homo sapiens
2 Median levels of drugs in CSF were smaller than expected, as follows: 4.4 microg/ml for cefotaxime, 3.2 microg/ml for desacetylcefotaxime, and 1.7 microg/ml for vancomycin. Cefotaxime colony stimulating factor 2 Homo sapiens
3 The median CSF bactericidal titer against an intermediately cefotaxime-resistant pneumococcus was 1:4. Cefotaxime colony stimulating factor 2 Homo sapiens