Title : Recovery of hypothalamic NMDA-induced c-fos expression following neonatal glutamate (MSG) lesions.

Pub. Date : 1997 Aug 18

PMID : 9298238






3 Functional Relationships(s)
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1 Recovery of hypothalamic NMDA-induced c-fos expression following neonatal glutamate (MSG) lesions. N-Methylaspartate Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 Groups of neonatal (postnatal day (PD) 2) pups were injected with MSG, then stimulated on subsequent days (PD 3-29) with NMDA, known to induce c-fos expression in ARC. N-Methylaspartate Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
3 We conclude that the recovery of hypothalamic function (i.e., onset of puberty) after a neonatal MSG lesion is coincident with the reappearance of a normal pattern of c-fos expression in response to NMDA stimulation. N-Methylaspartate Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus