Pub. Date : 1997 Sep 4
PMID : 9294614
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of caspases in mediating TG-induced apoptosis was investigated in the Bcl-2-negative human breast cancer cell line, MDA-MB-468. | Thapsigargin | BCL2 apoptosis regulator | Homo sapiens |
| 2 | Apoptosis developed in MDA-MB-468 cells over a period of 24-72 h following treatment with 100 nM TG, and was prevented by Bcl-2 overexpression. | Thapsigargin | BCL2 apoptosis regulator | Homo sapiens |
| 3 | These findings indicate that TG-induced apoptosis of MDA-MB-468 breast cancer cells is subject to inhibition by Bcl-2 and is mediated by caspase activity. | Thapsigargin | BCL2 apoptosis regulator | Homo sapiens |