Title : Does nitric oxide contribute to the negative chronotropic and inotropic effects of endothelin-1 in the heart?

Pub. Date : 1997 Aug 6

PMID : 9286621






2 Functional Relationships(s)
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1 The effects of endothelin-1 on the isoprenaline-induced cyclic AMP accumulation were not influenced by N omega-nitro-L-arginine methyl ester either. Isoproterenol endothelin 1 Homo sapiens
2 These results indicate that the negative chronotropic and inotropic effects of endothelin-1 in the presence of isoprenaline in mammalian cardiac muscle do not involve the nitric oxide-mediated signaling pathway. Isoproterenol endothelin 1 Homo sapiens