Protein Name endothelin 1
Organism Homo sapiens
Gene ID 1906
Gene Symbol


UniProt P05305 (EDN1_HUMAN), Q6FH53 (Q6FH53_HUMAN)
Relationships Total Number of functionally related compound(s) : 1547
Total Number of Articles : 3044

endothelin 1

Gene Summary

This gene encodes a preproprotein that is proteolytically processed to generate a secreted peptide that belongs to the endothelin/sarafotoxin family. This peptide is a potent vasoconstrictor and its cognate receptors are therapeutic targets in the treatment of pulmonary arterial hypertension. Aberrant expression of this gene may promote tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

  • endothelin-1
  • preproendothelin-1
  • ARCND3
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