Title : Antiapoptotic action of 1,25-dihydroxyvitamin D3 is associated with increased mitochondrial MCL-1 and RAF-1 proteins and reduced release of cytochrome c.

Pub. Date : 1997 Aug 25

PMID : 9281370






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The increase in Mcl-1 protein levels correlates with a reduced extent of apoptotic cell death induced by etoposide or the calcium ionophore A23187. Etoposide MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 The Mcl-1 protein is primarily localized in the mitochondria, and etoposide- or A23187-induced cytochrome c release is reduced in cells in which the mitochondria contain the Mcl-1 protein demonstrable by immunoblots. Etoposide MCL1 apoptosis regulator, BCL2 family member Homo sapiens