Title : Carboxyl-directed pegylation of brain-derived neurotrophic factor markedly reduces systemic clearance with minimal loss of biologic activity.

Pub. Date : 1997 Aug

PMID : 9279893






1 Functional Relationships(s)
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1 METHODS: PEG molecules with terminal hydrazide (Hz) moieties of molecular weight 2,000 (PEG2000-Hz) or 5,000 (PEG5000-Hz) Daltons were coupled to BDNF carboxyls using carbodiimide. Carbodiimides brain derived neurotrophic factor Homo sapiens