Protein Name brain derived neurotrophic factor
Organism Homo sapiens
Gene ID 627
Gene Symbol


UniProt P23560 (BDNF_HUMAN), A0A0E3SU01 (A0A0E3SU01_HUMAN)
Relationships Total Number of functionally related compound(s) : 1289
Total Number of Articles : 2954

brain derived neurotrophic factor

Gene Summary

This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]

  • brain-derived neurotrophic factor
  • abrineurin
  • neurotrophin
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