Pub. Date : 1997 Sep 1
PMID : 9278333
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here we show that TGF-beta1 induces the expression of macrophage-CSF (M-CSF) in vascular endothelial cells via a signaling pathway(s) involving hydrogen peroxide (H2O2). | Hydrogen Peroxide | colony stimulating factor 1 | Homo sapiens |
| 2 | Here we show that TGF-beta1 induces the expression of macrophage-CSF (M-CSF) in vascular endothelial cells via a signaling pathway(s) involving hydrogen peroxide (H2O2). | Hydrogen Peroxide | colony stimulating factor 1 | Homo sapiens |
| 3 | Here we show that TGF-beta1 induces the expression of macrophage-CSF (M-CSF) in vascular endothelial cells via a signaling pathway(s) involving hydrogen peroxide (H2O2). | Hydrogen Peroxide | colony stimulating factor 1 | Homo sapiens |
| 4 | Here we show that TGF-beta1 induces the expression of macrophage-CSF (M-CSF) in vascular endothelial cells via a signaling pathway(s) involving hydrogen peroxide (H2O2). | Hydrogen Peroxide | colony stimulating factor 1 | Homo sapiens |
| 5 | Furthermore, the TGF-beta1-induced M-CSF mRNA expression was inhibited by catalase, but not by superoxide dismutase, suggesting that H2O2 rather than superoxide anion (O2.-) is the primary mediator of the effects of TGF-beta1. | Hydrogen Peroxide | colony stimulating factor 1 | Homo sapiens |
| 6 | In a concentration-dependent manner, treatment with exogenous H2O2 produced 14- and 4.6-fold increases in M-CSF promoter activity and mRNA expression, respectively. | Hydrogen Peroxide | colony stimulating factor 1 | Homo sapiens |
| 7 | These results indicate that the generation of H2O2 and activation of NF-kappaB by TGF-beta1 are required for the induction of M-CSF gene transcription. | Hydrogen Peroxide | colony stimulating factor 1 | Homo sapiens |