Title : Compromised mitochondrial function leads to increased cytosolic calcium and to activation of MAP kinases.

Pub. Date : 1997 Sep 2

PMID : 9275188






3 Functional Relationships(s)
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1 We have investigated in rat pheochromacytoma PC12 cells the activation of the mitogen-activated protein kinases ERK1 and ERK2 by the mitochondrial uncoupler carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone (FCCP). Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone mitogen activated protein kinase 3 Rattus norvegicus
2 We have investigated in rat pheochromacytoma PC12 cells the activation of the mitogen-activated protein kinases ERK1 and ERK2 by the mitochondrial uncoupler carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone (FCCP). Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone mitogen activated protein kinase 3 Rattus norvegicus
3 Chelation of cytosolic calcium with dimethyl bis-(o-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid abolished the FCCP-stimulated rise in internal calcium, as well as the tyrosine phosphorylation and the activation of the ERKs. Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone mitogen activated protein kinase 3 Rattus norvegicus