Pub. Date : 1997 Aug 15
PMID : 9269990
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The DNA repair protein O6-methylguanine-DNA methyltransferase protects against skin tumor formation induced by antineoplastic chloroethylnitrosourea. | 1-(2-chloroethyl)-1-nitrosourea | O-6-methylguanine-DNA methyltransferase | Mus musculus |
| 2 | Because secondary tumor formation is a serious threat in chemotherapy with these drugs, we explored whether and to what extent the DNA repair protein DNA-O6-methylguanine:protein-L-cysteine S-methyltransferase (MGMT) protects against CNU-induced tumors. | 1-(2-chloroethyl)-1-nitrosourea | O-6-methylguanine-DNA methyltransferase | Mus musculus |
| 3 | Because secondary tumor formation is a serious threat in chemotherapy with these drugs, we explored whether and to what extent the DNA repair protein DNA-O6-methylguanine:protein-L-cysteine S-methyltransferase (MGMT) protects against CNU-induced tumors. | 1-(2-chloroethyl)-1-nitrosourea | O-6-methylguanine-DNA methyltransferase | Mus musculus |
| 4 | The results provide clear evidence that MGMT exerts protection against CNU-induced cancer. | 1-(2-chloroethyl)-1-nitrosourea | O-6-methylguanine-DNA methyltransferase | Mus musculus |
| 5 | Our data also indicate that O6-chloroethylguanine, which is repaired by MGMT, is a main precarcinogenic CNU-induced DNA lesion. | 1-(2-chloroethyl)-1-nitrosourea | O-6-methylguanine-DNA methyltransferase | Mus musculus |