Pub. Date : 1997 Oct
PMID : 9266775
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pretreatment with the 5-HT-1A agonists (+)8-OH-DPAT (0.001-0.1 mg/kg) and LY274600 (0.3-3.0 mg/kg) either had no affect or exacerbated the nicotine-withdrawal-enhanced startle response. | Nicotine | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |
| 2 | Pretreatment with the 5-HT-1A antagonists NAN-190 (1-3 mg/kg), LY206130 (1-10 mg/kg), or WAY-100635 (0.1-1.0 mg/kg) blocked the increase in the startle response caused by nicotine withdrawal at doses that had no effect on baseline startle responses. | Nicotine | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |
| 3 | These data indicate that 5-HT-1A receptors play a role in the neurophysiology of nicotine withdrawal. | Nicotine | 5-hydroxytryptamine receptor 1A | Rattus norvegicus |