Title : Novel connections between NADPH-induced lipid peroxidation and cytochrome P450 inactivation, and antioxidant and enzyme protective properties of estradiol in gonadal membranes.

Pub. Date : 1997 Feb

PMID : 9257124






1 Functional Relationships(s)
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1 NADPH (300 microM) causes a 3.6-fold stimulation of malondialdehyde formation (thiobarbituric acid-reactive substances) and a 29% cytochrome P450c17 loss within 1 h at 37 degrees C, but has no effect on lipid peroxidation in the presence of the iron chelator desferrioxamine. NADP cytochrome P450 family 17 subfamily A member 1 Homo sapiens