Title : Tacrolimus oral bioavailability doubles with coadministration of ketoconazole.

Pub. Date : 1997 Jul

PMID : 9246018






1 Functional Relationships(s)
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1 OBJECTIVE: To quantitate the effect of ketoconazole, an azole antifungal agent and potent inhibitor of CYP3A4 and P-glycoprotein, on the bioavailability of tacrolimus, a substrate of the CYP3A system and of P-glycoprotein. Tacrolimus cytochrome P450 family 3 subfamily A member 4 Homo sapiens