Title : Structure-based perspectives on B12-dependent enzymes.

Pub. Date : 1997

PMID : 9242908






1 Functional Relationships(s)
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1 These structures reveal that the B12 cofactor undergoes a major conformational change on binding to the apoenzymes of methionine synthase and methylmalonyl-coenzyme A mutase: The dimethylbenzimidazole ligand to the cobalt is displaced by a histidine residue from the protein. 5,6-dimethylbenzimidazole 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens