Title : Parathyroid hormone inhibits Na(+)-K(+)-ATPase through Gq/G11 and the calcium-independent phospholipase A2.

Pub. Date : 1997 Jun

PMID : 9227640






4 Functional Relationships(s)
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1 Previous studies from this laboratory have demonstrated that the 3-34 analog of parathyroid hormone (PTH) causes a 15-30% inhibition of Na(+)-K(+)-adenosinetriphosphatase (Na(+)-K(+)-ATPase) activity in rat renal proximal tubules through the generation of an increase in intracellular arachidonic acid, followed by its conversion to 20-hydroxyeicosatetraenoic acid (20-HETE) [C. P. Ribeiro and L. J. Mandel. 20-hydroxy-5,8,11,14-eicosatetraenoic acid parathyroid hormone Rattus norvegicus
2 Previous studies from this laboratory have demonstrated that the 3-34 analog of parathyroid hormone (PTH) causes a 15-30% inhibition of Na(+)-K(+)-adenosinetriphosphatase (Na(+)-K(+)-ATPase) activity in rat renal proximal tubules through the generation of an increase in intracellular arachidonic acid, followed by its conversion to 20-hydroxyeicosatetraenoic acid (20-HETE) [C. P. Ribeiro and L. J. Mandel. 20-hydroxy-5,8,11,14-eicosatetraenoic acid parathyroid hormone Rattus norvegicus
3 Previous studies from this laboratory have demonstrated that the 3-34 analog of parathyroid hormone (PTH) causes a 15-30% inhibition of Na(+)-K(+)-adenosinetriphosphatase (Na(+)-K(+)-ATPase) activity in rat renal proximal tubules through the generation of an increase in intracellular arachidonic acid, followed by its conversion to 20-hydroxyeicosatetraenoic acid (20-HETE) [C. P. Ribeiro and L. J. Mandel. 20-hydroxy-5,8,11,14-eicosatetraenoic acid parathyroid hormone Rattus norvegicus
4 Previous studies from this laboratory have demonstrated that the 3-34 analog of parathyroid hormone (PTH) causes a 15-30% inhibition of Na(+)-K(+)-adenosinetriphosphatase (Na(+)-K(+)-ATPase) activity in rat renal proximal tubules through the generation of an increase in intracellular arachidonic acid, followed by its conversion to 20-hydroxyeicosatetraenoic acid (20-HETE) [C. P. Ribeiro and L. J. Mandel. 20-hydroxy-5,8,11,14-eicosatetraenoic acid parathyroid hormone Rattus norvegicus