| Protein Name | parathyroid hormone |
|---|---|
| Organism | Rattus norvegicus |
| Gene ID | 24694 |
| Gene Symbol | Pth |
| UniProt | P04089 (PTHY_RAT) |
| Relationships |
Total Number of functionally related compound(s) :
652
Total Number of Articles : 1370 |
Description |
parathyroid hormone |
| Gene Summary |
Enables hormone activity; peptide hormone receptor binding activity; and type 1 parathyroid hormone receptor binding activity. Involved in several processes, including Rho protein signal transduction; negative regulation of chondrocyte differentiation; and regulation of bone mineralization. Acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway and cellular calcium ion homeostasis. Located in extracellular space. Used to study several diseases, including chronic kidney disease; hyperphosphatemia; nephrocalcinosis; osteoporosis; and secondary hyperparathyroidism. Biomarker of autosomal dominant hypocalcemia; kidney failure (multiple); osteoporosis; and secondary hyperparathyroidism. Human ortholog(s) of this gene implicated in several diseases, including chronic kidney disease; diabetes mellitus (multiple); familial isolated hypoparathyroidism; hyperphosphatemia; and secondary hyperparathyroidism. Orthologous to human PTH (parathyroid hormone). [provided by Alliance of Genome Resources, Apr 2022] |
| synonyms |
|
| Properties | |