Title : Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.

Pub. Date : 1997 Jul 1

PMID : 9202063






1 Functional Relationships(s)
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1 Oral feeding of LY333531 prevented the increased mRNA expression of TGF-beta1 and extracellular matrix components such as fibronectin and alpha1(IV) collagen in the glomeruli of diabetic rats in parallel with inhibition of glomerular PKC activity. ruboxistaurin transforming growth factor, beta 1 Rattus norvegicus