Protein Name transforming growth factor, beta 1
Organism Rattus norvegicus
Gene ID 59086
Gene Symbol


UniProt P17246 (TGFB1_RAT)
Relationships Total Number of functionally related compound(s) : 1730
Total Number of Articles : 3699

transforming growth factor, beta 1

Gene Summary

Enables identical protein binding activity and protein N-terminus binding activity. Involved in several processes, including animal organ development; cellular response to hormone stimulus; and regulation of epithelial cell proliferation. Acts upstream of or within positive regulation of smooth muscle cell differentiation. Located in several cellular components, including cell surface; neuronal cell body; and secretory granule. Used to study chronic obstructive pulmonary disease; familial hyperlipidemia; hypertension; proteinuria; and pulmonary fibrosis. Biomarker of several diseases, including allergic rhinitis; artery disease (multiple); cerebrovascular disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; Camurati-Engelmann disease; aphthous stomatitis; artery disease (multiple); and lung disease (multiple). Orthologous to human TGFB1 (transforming growth factor beta 1). [provided by Alliance of Genome Resources, Apr 2022]

  • transforming growth factor beta-1 proprotein
  • TGF-beta-1
  • Tgfb
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