Pub. Date : 1997 May
PMID : 9164418
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of sorivudine on dihydropyrimidine dehydrogenase activity in patients with acute herpes zoster. | sorivudine | dihydropyrimidine dehydrogenase | Homo sapiens |
| 2 | The objective of this study was to assess the time course of recovery of DPD activity after oral administration of sorivudine in patients with herpes zoster and to correlate restoration of DPD activity and levels of uracil with the elimination of sorivudine and its metabolite BVU from the circulation. | sorivudine | dihydropyrimidine dehydrogenase | Homo sapiens |
| 3 | DPD activity in PBMCs, which was completely suppressed in 18 of the 19 subjects and markedly suppressed in the remaining subject during administration of sorivudine, recovered to baseline levels within 19 days after the last dose of sorivudine in all subjects and within 14 days in all but one of the subjects. | sorivudine | dihydropyrimidine dehydrogenase | Homo sapiens |
| 4 | DPD activity in PBMCs, which was completely suppressed in 18 of the 19 subjects and markedly suppressed in the remaining subject during administration of sorivudine, recovered to baseline levels within 19 days after the last dose of sorivudine in all subjects and within 14 days in all but one of the subjects. | sorivudine | dihydropyrimidine dehydrogenase | Homo sapiens |
| 5 | The elevated uracil concentrations produced by inhibition of DPD activity fell rapidly after cessation of sorivudine administration and also were temporally associated with elimination of BVU from the circulation. | sorivudine | dihydropyrimidine dehydrogenase | Homo sapiens |
| 6 | CONCLUSIONS: This study indicates that sorivudine therapy is associated with a profound depression of DPD activity. | sorivudine | dihydropyrimidine dehydrogenase | Homo sapiens |
| 7 | Recovery of DPD activity occurred within 4 weeks of the completion of sorivudine therapy, which indicates that fluorinated pyrimidines may be safely administered 4 weeks after completion of sorivudine therapy. | sorivudine | dihydropyrimidine dehydrogenase | Homo sapiens |