Pub. Date : 1997 Apr 30
PMID : 9163728
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Isolation and characterization of daunorubicin-resistant AML-2 sublines. | Daunorubicin | RUNX family transcription factor 3 | Homo sapiens |
| 2 | An attempt was made to isolate resistant sublines of acute myelogenous leukemia (OCI/ AML-2) cells by chronic exposure to gradually increasing concentrations of daunorubicin in order to determine the mechanism of its resistance to this drug. | Daunorubicin | RUNX family transcription factor 3 | Homo sapiens |
| 3 | The daunorubicin-resistant AML-2 sublines also showed cross resistance to various anticancer drugs including another anthracycline doxorubicin, a Vinca alkaloid vincristine, and an epipodophyllotoxin etoposide. | Daunorubicin | RUNX family transcription factor 3 | Homo sapiens |
| 4 | These daunorubicin-resistant AML-2 sublines could provide a useful model for the study of multidrug resistance mediated by PGP. | Daunorubicin | RUNX family transcription factor 3 | Homo sapiens |