CPRiL

RUNX3

RUNX family transcription factor 3

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

• runt-related transcription factor 3
• CBF-alpha-3
• PEA2 alpha C
PEBP2 alpha C
SL3-3 enhancer factor 1 alpha C subunit
SL3/AKV core-binding factor alpha C subunit
acute myeloid leukemia 2 protein
acute myeloid leukemia gene 2
core-binding factor subunit alpha-3
core-binding factor, runt domain, alpha subunit 3
oncogene AML-2
polyomavirus enhancer-binding protein 2 alpha C subunit
runt related transcription factor 3
transcription factor AML2
AML2
CBFA3
PEBP2aC