Pub. Date : 1997 May
PMID : 9163675
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | EGF- and CPA-induced mitogenic stimuli are differentially down-regulated by TGF-beta1 in cultured rat hepatocytes. | Cyproterone Acetate | transforming growth factor, beta 1 | Rattus norvegicus |
| 2 | The corresponding down-regulation of CPA-induced PCNA expression required a 3- to 5-fold higher TGF-beta1 concentration than for EGF-induced expression. | Cyproterone Acetate | transforming growth factor, beta 1 | Rattus norvegicus |
| 3 | In contrast, CPA-exposed hepatocytes become vulnerable to and EGF-exposed cells protected against the apoptosis-inducing activity of TGF-beta1 (>0.1 ng/ml). | Cyproterone Acetate | transforming growth factor, beta 1 | Rattus norvegicus |
| 4 | It is concluded that EGF and CPA induce their growth stimuli preferentially in the periportal area of the liver but in different hepatocyte sub-populations, which differ in their down-regulation of premitotic events by TGF-beta1. | Cyproterone Acetate | transforming growth factor, beta 1 | Rattus norvegicus |
| 5 | At low TGF-beta1 concentrations, EGF-stimulated cells shift back into a resting cell cycle phase, whereas CPA-treated hepatocytes are eliminated by apoptosis at higher TGF-beta1 concentrations. | Cyproterone Acetate | transforming growth factor, beta 1 | Rattus norvegicus |