Title : Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines.

Pub. Date : 1997 May 15

PMID : 9157990






3 Functional Relationships(s)
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1 CYP3A4, CYP2C8, and CYP2C9 protein levels were also increased by exposure of the hepatocytes to cyclophosphamide or ifosfamide (50 microM), which thereby enhanced their own rates of 4-hydroxylation in the cultured hepatocytes. Cyclophosphamide cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 In one human hepatocyte culture that contained the polymorphically expressed CYP3A5 in addition to the more widely expressed CYP3A4, only CYP3A4 was induced by cyclophosphamide, ifosfamide, and rifampin. Cyclophosphamide cytochrome P450 family 3 subfamily A member 4 Homo sapiens
3 In one human hepatocyte culture that contained the polymorphically expressed CYP3A5 in addition to the more widely expressed CYP3A4, only CYP3A4 was induced by cyclophosphamide, ifosfamide, and rifampin. Cyclophosphamide cytochrome P450 family 3 subfamily A member 4 Homo sapiens