Title : NO-dependent and NO-independent IL-1 production by a human colonic epithelial cell line under inflammatory stress.

Pub. Date : 1997 May

PMID : 9154326






2 Functional Relationships(s)
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1 The use of NG-monomethyl-L-arginine (L-NMMA), an inhibitor of NOS, led to the demonstration of two distinct signalling pathways in IL-1 production by HT29-Cl.16E cells, one dependent on NO (L-NMMA-sensitive) under treatment with IFN gamma/TNF alpha/IL-1 beta, and the other independent of NO (L-NMMA-insensitive) under treatment with <protein-id="3458">IFN gamma/TNF alpha. omega-N-Methylarginine interferon gamma Homo sapiens
2 The use of NG-monomethyl-L-arginine (L-NMMA), an inhibitor of NOS, led to the demonstration of two distinct signalling pathways in IL-1 production by HT29-Cl.16E cells, one dependent on NO (L-NMMA-sensitive) under treatment with IFN gamma/TNF alpha/IL-1 beta, and the other independent of NO (L-NMMA-insensitive) under treatment with <protein-id="3458">IFN gamma/TNF alpha. omega-N-Methylarginine interferon gamma Homo sapiens