Pub. Date : 1997 Jan
PMID : 9147616
5 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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| 1 | Potentiation of antitumor efficacy of paclitaxel by recombinant tumor necrosis factor-alpha. | Paclitaxel | tumor necrosis factor | Mus musculus | ||
| 2 | Our aim was to determine whether TNF increases the antitumor efficacy of paclitaxel and if so whether the increase is mediated through the enhancement of apoptosis induction by paclitaxel. | Paclitaxel | tumor necrosis factor | Mus musculus | ||
| 3 | Histological analysis of treated MCa-K tumors revealed that TNF alone did not induce apoptosis of tumor cells, but in the combination it enhanced the apoptotic response to paclitaxel. | Paclitaxel | tumor necrosis factor | Mus musculus | ||
| 4 | Thus, TNF increased the antitumor efficacy of paclitaxel by enhancing cellular sensitivity to paclitaxel"s induction of apoptosis. | Paclitaxel | tumor necrosis factor | Mus musculus | ||
| 5 | Thus, TNF increased the antitumor efficacy of paclitaxel by enhancing cellular sensitivity to paclitaxel"s induction of apoptosis. | Paclitaxel | tumor necrosis factor | Mus musculus | ||