Title : Noncoplanar PCB 95 alters microsomal calcium transport by an immunophilin FKBP12-dependent mechanism.

Pub. Date : 1997 May

PMID : 9145907






2 Functional Relationships(s)
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1 Disruption of the association between immunophilin FKBP12 and Ry1R with FK 506 or rapamycin completely eliminates PCB 95-enhanced binding of [3H]ryanodine (IC50 approximately 35 microM) to Ry1R and PCB 95-induced release of Ca2+ from actively loaded SR vesicles (IC50 approximately 11 microM), demonstrating a FKBP12-dependent mechanism. Tacrolimus FKBP prolyl isomerase 1A Homo sapiens
2 Disruption of the association between immunophilin FKBP12 and Ry1R with FK 506 or rapamycin completely eliminates PCB 95-enhanced binding of [3H]ryanodine (IC50 approximately 35 microM) to Ry1R and PCB 95-induced release of Ca2+ from actively loaded SR vesicles (IC50 approximately 11 microM), demonstrating a FKBP12-dependent mechanism. Tacrolimus FKBP prolyl isomerase 1A Homo sapiens