Title : Effect of cell density and epidermal growth factor on the inducible expression of CYP3A and CYP1A genes in human hepatocytes in primary culture.

Pub. Date : 1997 May

PMID : 9141435






1 Functional Relationships(s)
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1 In the absence of EGF, the accumulation of CYP3A4 and CYP1A2 messenger RNAs (mRNAs) in response to their respective inducers (rifampicin and dioxin) was dramatically decreased in subconfluent culture with respect to confluent cultures. Rifampin cytochrome P450 family 1 subfamily A member 2 Homo sapiens