Title : Insulin receptor substrate (IRS)-2 is dephosphorylated more rapidly than IRS-1 via its association with phosphatidylinositol 3-kinase in skeletal muscle cells.

Pub. Date : 1997 May 9

PMID : 9139749






1 Functional Relationships(s)
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1 Indeed, stimulation with insulin or insulin-like growth factor I led to the rapid tyrosine phosphorylation of both IRS-1 and IRS-2, which in turn activated phosphatidylinositol (PI) 3-kinase in L6 cells and rat skeletal muscle. Phosphatidylinositols insulin receptor substrate 1 Rattus norvegicus