Title : A blocker of nitric oxide synthase, NG-nitro-L-arginine methyl ester, attenuates light-induced Fos protein expression in rat suprachiasmatic nucleus.

Pub. Date : 1997 Mar 7

PMID : 9132683






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1 A blocker of nitric oxide synthase, NG-nitro-L-arginine methyl ester, attenuates light-induced Fos protein expression in rat suprachiasmatic nucleus. NG-Nitroarginine Methyl Ester Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 In the present study we investigated this hypothesis by assessing in rats the effect of treatment with the NOS blocker, NG-nitro-L-arginine methyl ester (L-NAME), on light-induced expression of the transcription factor Fos, a cellular marker of light signaling in the SCN. NG-Nitroarginine Methyl Ester Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
3 In the present study we investigated this hypothesis by assessing in rats the effect of treatment with the NOS blocker, NG-nitro-L-arginine methyl ester (L-NAME), on light-induced expression of the transcription factor Fos, a cellular marker of light signaling in the SCN. NG-Nitroarginine Methyl Ester Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
4 We found that systemic administration of L-NAME (100 mg/kg) but not of the inactive analog, D-NAME, significantly attenuates light-induced expression of Fos immunoreactivity in the SCN. NG-Nitroarginine Methyl Ester Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus