Pub. Date : 1997 Feb
PMID : 9131953
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: Cytochrome P4503A (CYP3A) activity was reduced in all subjects by a mean level of 26% following clarithromycin treatment. | Clarithromycin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | RESULTS: Cytochrome P4503A (CYP3A) activity was reduced in all subjects by a mean level of 26% following clarithromycin treatment. | Clarithromycin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | CONCLUSIONS: As clarithromycin was shown to inhibit CYP3A activity in all subjects tested, we recommend that a high degree of caution be exercised when clarithromycin is administered to patients receiving cyclosporine therapy or other drugs known to be eliminated by CYP3A-mediated metabolism. | Clarithromycin | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |